Quite possibly, according to Deadline:
A little over a week ago, Deadline revealed that Universal Pictures had made a deal for another comedy that Bridesmaids director Paul Feig would write, helm and produce with Judd Apatow. There was no title and the plot was under wraps. I've learned a little bit more. The unconventional love story is about a guy who becomes obsessed with a woman. The template for the guy is Jon Hamm, and the gal is Melissa McCarthy. While I'm cautioned there are no negotiations and it is all very early, it makes perfect sense that both of these thesps will be courted to star in this Feig-directed comedy. Mad Men's Hamm played a fabulously insensitive douchebag playboy in Bridesmaids. As for Mike & Molly star McCarthy, she stole every scene she was in, no easy feat in that strong ensemble cast. If Universal and Apatow aren't figuring out ways to build comedies around McCarthy, they're crazy.
-Joey's Two Cents: I think they'd be a great pairing...thoughts?